Preparation, Characterization, Anti-cancer and Antibacterial Evaluation of New Schiff base and Tetrazole Derivatives
DOI:
https://doi.org/10.25130/tjps.v28i2.1333Keywords:
Anticancer, Schiff base, Tetrazole, Anti-bacterial, AzoAbstract
This work involved the synthesis of tetrazole derivatives 4,4'-(((sulfonylbis(4,1-phenylene))bis(diazene-2,1-dil))bis(2-(1-(4-R)phenyl]-4),5-Dihydro-1H-tetrazol-5-yl(phenol) (where R = OH or OCH3) through the reaction of the substituted amine in THF as a solvent with sodium azide. FT-IR 1H-NMR Spectrophotometric methods were used to characterize the prepared compounds. The antibacterial activity against four types of bacteria was studied. It was proven that tetrazole compounds were more effective than the compounds from which they were derived. The anticancer activity was measured against MCF-7 strains of human breast cells of the synthesized compounds.
Downloads
Published
How to Cite
License
Copyright (c) 2023 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.