Cytogenetic Effects Of Fumagillin On Male Mice (Mus musculus)
DOI:
https://doi.org/10.25130/tjps.v22i8.852Keywords:
Cytogenetic - Fumagillin - Mice - Mitotic Index- chromosome aberrationAbstract
The cytogenetic effects of Fumagillin were evaluated according to Mitotic Index (M.I) and aberration of metaphase chromosomes in bone marrow cells(CA) of white mice. The fumagillin was given as repeated oral gavages for 7 successive days after preparing the doses 10,15 at concentrations 20 mg/kg.b.wt. in 50% of sugar syrup . The positive control was given single I.p. dose of 20 mg/kg.b.wt. of methotrexate. The three dosages 10, 15, and 20 mg/kg.b.wt of Fumagillin induced significant decrease in mitotic index (3.90 ± 0.29, 3.60 ± 1.80, and 2.90 ±0.18) respectively compared with (7.10 ±0.29) for negative control. The results showed that the two dosages 15 and 20 mg/kg.b.wt of Fumagillin induced significant increase in the frequency of the chromosome aberration in bone marrow cells of the mice in the these groups (9.00± 0.92, 17.20 ± 1.42) respectively compared with (6.00 ±0.83) for negative control. The obtained result revealed the genetic and cellular toxic reaction of Fumagillin within the high and medium limits studied doses.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
