Study the obesity effect on liver and kidney tissues of female rats followed by treatment these effects by using aqueous extract of grape leaves

Abstract

The present study was designed to identify the effect of obesity for induction histological lesions to liver and kidneys in female rats Rattus norvegicus. and treated with herbal therapy (aqueous extract of grape leaves) The present study used 16 female rats which distributed randomly into four groups (each group containing four female) the first group was control group administrated only normal diet and water, the second group was fed a high fat diet for three months without treatment, the third and fourth groups fed a high fat diet for three months and treated with aqueous extract of grape leaves100 and 200 mg / kg of body weight respectively for one month. The results showed that the effect of a high fat diet on the liver included primary seclerosing bile ducts, infiltration of lymphocytes and congestion of blood in the blood vessel with the absence of cellular arrangement of liver tissue, while the kidney tissue show desquamation epithelial lining cells in some tubules with damage of some renal glomeruli.  When the aqueous extract of grape leaves used, most tissues in the liver and kidneys back and appear semi-normal state.