Study the effect of obesity on the liver and kidney of the white rats embryos followed by using of grape seed oil to treat it. (morphological and histological study)

Abstract

The present study was designed to identify the effect of obesity on liver and kidneys rats fetuses Rattus norvegicus and the ability of grape seeds oil to treat these effects.

The present study used 12 female rat which divided randomly into three groups (each group containing four female) the first group was control group administrated only normal diet and water, the second group was fed a high fat diet for three months, the third groups fed a high fat diet for three months and treated with grape seed oil at a dose of 0.1 ml/ kg body weight. The results showed the effect of a high fat diet lead to inducing morphological changes in fetuses included decrease in the numbers and sizes of fetuses in the horns of uterus with shortness in the limbs. The histological lesions included necrosis, degenerative changes, in liver tissue with increased in sinusoids diameter. About kidneys, the lesions included desquamation of epithelium of some proximal convoluted tubules with damage of some of its, also damage glomeruli. After the treatment with grape seeds oil observed most of the embryos appeared normal in size and number without any lesions in the liver and kidney tissue of embryos.