The Potential Effect of Grape Seeds Extract against Lead toxicity That Induces Infertility to Male Rats
DOI:
https://doi.org/10.25130/tjps.v23i1.481Keywords:
: Grape; lead (Pb); sperm analysis; oxidative stress.Abstract
The present study was designed to find the role, of grape seed extract against lead toxicity. Study was used 25 male rats that divided randomly to five groups (5 rats in each group) and the treatment continue four week in each group, control group administrated with normal saline, rats group treatment with (orally) lead (Pb), third group received lead (Pb) 100mg/kg and 50mg/kg seed extract, fourth group received lead (Pb) and 100mg/kg seed extract, fifth group received lead (Pb) and 200mg/kg seed extract. Rats group received lead show significant (P<0.05) decrease in counts, motility of sperm and increase the deformity of sperms. Other wise, rats group received lead show significant (P<0.05) decrease in glutathione (GSH), catalase (CAT) and increase levels of malonedialdehyied (MDA) compared with control group. The treated group with seed extract at different doses, sperm parameters and oxidative stress show gradual recovery. In 200mg/kg dose of seed extract, all parameters of study back to the normal ranges. It was concluded from this study that grape seed extract has important role against toxicity of lead in male rats.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.