Clinical study of copeptin in serum patiants of heart diseases

Abstract

The study  included the estimation  copeptin level  in serum of healthy and  patients  with heart diseases .  The Results indicated that the level of copeptin in serum was (36.2±1.1 pg/mL) in control group for both sex, with the age range between ) 37 - 60 ≥ years) .while there was a significant increase in copeptin concentration in patients of the heart disease (106.8 ±2.1 pg/mL) compared with control group.  The results  also showed that  the concentration of copeptin was not affected by sex, age, body mass index and smoking, in both control and patients group . There was no significant differences in the concentration of copeptin in the case of hypertension , diabetes mellitus and statin taking  in patients group Results  revealed  a significant increase in the activity of (creatin kinase, peroxidase, glutamate oxaloacetate transferase, glutamate pyruvate transferase, lactate dehydrogenase,  lactoperoxidase) and concentration  of malondialdehyde, mholesterol, mriglyceride, low density lipoprotein, very low density lipoprotein, glucose, creatinine, c-reactive protein and copper in patients group . There was a significant decrease in the glutathione s-transferase activity, glutathione peroxidase activity and concentration  of  high density lipoprotein , glutathione, zinc and selenium.

Study of correlation coefficients between the concentration of copeptin and some clinical parameters in control and patients group showed that: the copeptin has a significant positive correlation with peroxidase activity, malondialdehyde in control and patients group and c-reactive protein ( in patients group only).  The copeptin has a significant negative correlation with glutathione peroxidase, glutathione s-transferase, glutathione and selenium  in control and patients group.