The effectiveness of inhibitory of Cinnamomum zeylanicum extract against Proteus mirabilis (invitro and invivo)

Abstract

The study designed to show the antimicrobial activity of cinnamomum zeylanicum extract against P. mirabilis. The present study was divided to two parts, the first part (invitro) including sensitivity test of P. mirabilis against extract and amoxicillin. where, the results of inhibition efficacy of extract toward P. mirabilis showed very high inhibition efficacy of extract, which reached to 30 mm, while amoxicillin showed non inhibition effect against bacterial growth. In the second part (in vivo) used 20 albino mice Mus musculus that divide randomly to four groups (each group consist 5 mice), first group; control group administrated only normal diet and water, second group; injected intraperitoneally with (2x10⁸ CFU/ml), third group; injected intraperitoneally with (2 x 10⁸ CFU/ ml) and treated with amoxicillin, forth group; injected intraperitoneally with (2 x 10⁸ CFU/ ml) and treated with extract. The urea and creatinine levels were increased and showed high significant changes (P < 0.01) in groups (second, third) compared with control group but its back to normal when treated with extract. The microscopic examination showed many changes in kidneys of groups (second, third) including damage glomerulus, convolute tubules, fibrosis, and infiltration of lymphocytes, congestion and thickening wall of blood vessels. The kidneys tissue in forth group showed recovery in the glomerulus and convolute tubules. It was concluded from this study that the cinnamomum zeylanicum has been antimicrobial activity against P. mirabilis.