Cross malformations and Histolgical Changes in Brain and Eyes of Mice and Their Embryos Exposed to Glue smoke

Abstract

Histological changes were detected in brain and eyes of female mice and their embryos as a result of exposure to the doses1500,2500 and 3500mg/kg body weight) of glue smoke given during the7^th day of pregnancy as till the18^th day of pregnancy. Data of behavioral changes were recorded of the2500and3500mg/kg body weight that included agitation, abnormal movements and hyperactivity. These changes continued for 30min were followed by fatigue, anorexia, and mice became located at one corner of the cageAbortions occurred at the rates15% and40%following the doses 2500 and 3500mg/kg body weight, respectively. This was coupled with the occurrence of  34%,65% and 80% doses of malformation due to the doses 1500,3500and3500mg/kg body weight respectively. Malformations included mongolism, stunted growth, head defects (encephalomeningocele and circular head which appeared as bird head), displacement of eyes and ears, skin wrinkling and flabness, skeletal deformities, and aberrations of limbs and tail.

Pathological lesions were developed on the fetuses included  hypercellularity of the cerebral cortex ,edema of the meninges and ophthalmic changes delayed growth and development of many parts of the eye, damage of the lens, edema of the outer plexiform layers of the retina and duplication of the retina. These results supported the putative pathological effect of glue smoke in brain and eyes of pregnant mice and their embryos.