Role Oxidative stress in formation Of kidney stones

Abstract

The study includes (90) people of males and females, whom (30) healthy peoples (16 males, 14 females) and (60) patients have kidney stones (33 males, 27 females) that aged ranged from (20 – 62) years.

The study was conducted to evaluated (MDA, SOD, Catalase ,total concentration of thiols, total concentration of protein and albumin) in blood serum of kidney stone patients. Also evaluated level of TAC, MDA, and Biochemical test (uric acid and Calcium) for 24 hours urine collection.

 The study showed significantly increase concentration of (MDA) that value in the serum of patients (48.813±6.614nmol/l) compared with control groups (17.689±4.176 nmol/l) in addition to significantly decrease in the level of (SOD, Catalase, total thiols, total proteins and albumin) in blood serum of patients, They were (39.46±6.95 U/ml), (293.5±26.08KU\l), (223.9±18.39µmol/ml), (6.584±0.532g\dl), (3.325±0.29 mg/dl) compared with control (64.52±8.42 U/ml), (509.01±43.41 KU\l), (401.36±37.42 µmol/ml), (8.500±0.321 g\dl), (4.5173±0.26 mg/dl) respectively at the level of probability (P ≤ 0.05)

The study also showed the presence of a significantly increase concentration of MDA, Uric acid, Calcium of urine patients they were (166.0±8.103nmol/l), (14.27±1.511mg/dl), (9.126±1.731mg/dl) comparing with controlling group which were (88.62±6.002 nmol/l), (6.671±0.561 mg/dl(, (6.946±0.904 mg/dl) respectively, the significantly decrease of the level of total anti-Oxidants in the urine of patients of urinary stones (45.90±8.063 µmol\l) compared with controlling group (98.0±12.757µmol\l) ,The highest incidence of urinary tract stones in the age group (31- 40) years and that the high percentage prevalence of kidney stones in male group (55%) compared with a female groups (45%).