Controlled release study for captopril by using polymer carboxymethyl cellulose

Authors

  • Reem Ibrahim Mahdi
  • R.R. AL-Samarrai
  • Ahmed A.Ahmed

DOI:

https://doi.org/10.25130/tjps.v22i4.738

Abstract

The present study was done to prepare tablet for captopril (CAP) which used in the treatment of hypertension and heart failure. CAP is mainly absorbed from the proximal intestine and to a lesser extent from the stomach. The tablets of CAP were prepared by using the polymer carboxymethyl cellulose (CMC) a captopril drug release system. The buffer solutions were use at (pH=12,7.4,8.5) as a media to release the drug similitude of the acidity index in stomach, in testiness, and blood plasma respective. It was accounted the concentrations of the drug that release in the above–mentioned solutions at the different temperature (25,30,37,40,45,) C°. The study was extended to the effect of the temperature and the acidity function on releasing the drug. The drug release from the polymers increased with  the temperature and the degree of the solution acidity. It was also studied the value of stability constant that increased with the temperature.

Downloads

Published

2023-01-28

How to Cite

Reem Ibrahim Mahdi, R.R. AL-Samarrai, & Ahmed A.Ahmed. (2023). Controlled release study for captopril by using polymer carboxymethyl cellulose. Tikrit Journal of Pure Science, 22(4), 87–98. https://doi.org/10.25130/tjps.v22i4.738

Issue

Vol. 22 No. 4 (2017)

Section

Articles

License

Copyright (c) 2023 Tikrit Journal of Pure Science

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.