Detection The Polymorphism in exon- 6 for gene PPAR-ᵧ in Obese Polycystic Ovarian Syndrome Women
DOI:
https://doi.org/10.25130/tjps.v22i1.602Abstract
Peroxisome Proliferator Activated Receptors Gamma (PPAR-ᵞ) is a nuclear transcription factor, which Protein receptors for insulin and have a significant role in insulin resistance and Type 2 Diabetes mellitus in addition to the role of the gene encoded in the differentiation Adipocyte and the development of Adipose tissue. at present research has been detected substitution silent mutation C T in the exon 6 of the gene PPAR-ᵧ in 111 women, including 73 obese women with Polycystic ovarian syndrome and 38 healthy women . in addition we determined certain biochemical variables (Blood Sugar, HDL-C, Triglycerides) and find a body mass index (BMI) and compared between the two groups of women where the results showed significant difference value of BMI and the concentration of each of the (Blood Sugar, HDL-C, Triglycerides) and at (0.05 and 0.01) among Patient women and Healthy the results showed significant difference in mutant T allele frequency between them . The value in Obese PCOS women was (0.336) compared to the value at the healthy women (0:29) this indicates the a correlation between substitution silent mutation C T in exon 6 for PPAR-ᵧ and disease
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
