The Relation between Kidney Injury Molecule -1 and its role as promising biomarker in kidney stone patients

Abstract

Urea and creatinine is the most sensitive markers of  Kidney Diseases progression in clinical practice, especially when combined with GFR, but these have  limitations. Hence, early, more sensitive, biomarkers are required. Recently, promising biomarkers have been identified for CKD progression such as kim-1 has been investigated as a novel biomarkers of kidney diseases progression. This study aimed to evaluate urinary Kidney Injury Molecule-1(KIM-1) in kidney stone patients.75 patients diagnosed with renal stone diseases and all patients were screened and followed up in the out-patients clinics in Salah Adin general hospital. controls were represented by 15 healthy volunteers. KIM-1, levels shows no significant changes within patients groups while shows that the KIM-1 levels were significantly increased in stone patients when compared with the healthy controls (P˂0.05). Total protein and S. Albumin levels significantly decreased in patients group compared to the controls levels while there was no significant changes within patients group. The current results suggest that  KIM-1 can consider as promising biomarker for diagnosis, clinical progression and investigations for kidney stone diseases.”