Synthesis, diagnosis and biological activity study of some heterocyclic compounds derived from 2-aminobenzothiazole

Abstract

This study includes synthesis of some benzothiazole derivatives from treatment 2 -aminothiazole with choroacyle chloride to form 1-hydrogen-benzothiazole-2yl-2-chloroastiamide (1).the last one was reacted with urea, thiurea, thiosymigarizaide, 2- amibenzothiazole and para- aminoaniline, respectively to form the compounds (2,6). Some shiff bases for 2-aminobenzothiazole (7,8) were prepared from the reacting with aromatic aldehydes and it was cycled by reaction with glycine to form two derivatives of amidazolidine (9,10). The prepared compounds were diagnosed by IR spectra and H¹NMR for proton, then, the bacterial susceptibility towards some prepared compounds (1,2,5,6,7) were estimated against E.coli and Proteus mirabilis .