Histopathological Effects Of Ethanolic Extract of Saffron Flowers Crocus sativus L. On Stomach And Small Intestine of White Mice Females Mus musculus

Abstract

The current study was designed to identify the histopathplogical effects of the ethanolic extract of saffron flowers on the stomach and small intestine of female adult mouse at the doses of 25, 50 mg / kg of body weight (b.w.) for the periods 15, 30 days and once a day. Behavioral changes were include rapid movement of the animals, a simple lack of appetite for water and food, excitation, hyperactivity, hostility, weakness and convulsions in the movement of mice. The results showed histopathological changes of the mice stomach and that was at the dose of 25 mg /kg of b.w. for the above periods, lymphatic cells infiltration between gastric glands cells in the mucosa and submucosa, as well as degeneration and necrosis of the cells of the gastric glands and edema, While at the dose of 50 mg /kg of b.w. and for the same above periods,  an increased lymphocytic infiltration with blood vessels congestion, degeneration and necrosis of a large number of cells in the muscularis mucosa were observed. tissue lesions were increased as the period of treating increased, while the small intestine and for the above periods histological changes at the dose of 25 mg /kg b.w. characterized by congestion of blood vessels lining the small intestine, lymphocyte infiltration and its extension to the muscularis, degeneration of the villi epithelial cells and hemorrhage between muscularis cells. At the dose of 50 mg/kg b.w. for the  above periods, acute lymphocyte and neutrophils infiltration in mucosa and sub mucosa were observed, as well as sever degeneration in their cells, coagulative necrosis was also observed in the entire  cells of the lining of the small intestine.