Cytogenetic study of Acute myelogenous Leukemia in Erbil City-Iraqi Kurdistan Region

Abstract

Acute myelogenous leukemia  is a blood disorder.  It is tenth most frequent cancer, and the third leading cause of cancer death through the world. Acute myeloid leukemia is clinically heterogeneous disorder characterized by multitude of chromosomal changes. The objective of the present study is to study frequency of chromosomal aberrations (CA) in peripheral blood lymphocytes of Acute myelogenous leukemia patients  in Erbil City. Blood samples were collected from 50 patients and 20 controls from both sex at different age groups. Because  Acute myeloid leukemia is a heterogeneous disorder; genetic factors, smoking habit, patients occupation, blood diseases, genetic diseases  and various environmental factors contribute to its development. Other factors was also studied included patient gender and age. The results showed that a significant increases in the chromosomal abnormalities in the patients  when compare  to control group and  that highest value of chromosomal aberrations was (Dicentric chromosome) which occurred in males at fourth age group (60-69), also it showed that most patients are males who are at age group(60-69)year, Also the results showed that most of patients have smoking habit especially males, and because environmental and occupational exposures to chemicals play an important role, So the most patients  have mylodysplasia blood disease.