Interstop [Dioraleze] Drug-induced hepatotoxicity and Liver Injury In Rats
DOI:
https://doi.org/10.25130/tjps.v25i4.264Keywords:
Interstop, Dioraleze, Anti-Diarrhea.Abstract
Interstop (Also known as Dioraleze) was the focus of this research paper to elaborate and find out the effect of Interstop administration on Hepatocytes in Rats.
Rats from both sexes were randomly distributed into three main groups as follows:
Group 1 (Control): Orally given distilled water daily for three weeks.
Group 2 (Treatment): Orally given 1mg/kg body weight Interstop daily for three weeks.
Group 3 (Overdose): orally given 2.5mg/kg body weight Interstop daily for three weeks.
At the end of the experiment, rats were dissected and the liver was obtained under aseptic technique for laboratory study.
Drug-induced liver disease is usually a result of metabolites that could affect the cell and tissue biochemistry directly or result in an immune response which was found in this study as the occurrence of several Vascular Sacs directly attached to the liver in all rats present in group 2 and 3. The sac ranged in size from 0.5 cm-1 cm compared to control that lacked the presence of any vascular sac.
Liver in both treatment groups showed several abnormalities after treatment compared to Group 1 which includes Karyolysis, pyknosis and Karyohexsis. Atrophy and necrosis in addition to degeneration of hepatocytes was seen.
In conclusion, Interstop has shown remarkable damaging effects on the Liver, especially when used without medical awareness and at higher doses than recommended, hence, leading to Hepatocyte abnormalities increasing organs malfunction and performance deficiency after long time of treatment.
Downloads
Published
How to Cite
License
Copyright (c) 2022 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
