The Adverse consequence of covid-19 causing liver and kidney dysfunctions

Authors

  • Omar Falah Ibrahim

DOI:

https://doi.org/10.25130/tjps.v27i5.12

Keywords:

(consequence of covid-19; multi-organ injury; covid-19 and kidney failure; covid-19 and liver injury; drugs adverse)‎

Abstract

The COVID-19 outbreak is a ‎substantial public health concern around the world. The most common ‎complication of COVID-19 infection ‎is lung damage. However, damage can occur in other organs, including ‎ liver, cardiac dysfunction, kidney ‎dysfunction, and intestine disorder.‎ This research aims is to evaluate the function of two main organs ‎in the human body, the ‎liver, and ‎kidney, assess the organ's function by measuring the clinical features and test abnormalities ‎in ‎COVID-19 ‎patients, and to compared with previous publications, and highlighted on adverse of ‎pharmacological utilized in ‎the treatment of covid-19 patients.‎ This study included collcting  the blood from 60 patients with an ‎average age of (58.718) was admitted between August and December ‎‎2021 to ‎Al-‎Shefa hospital in Al-Ramadi city with a severe infection of SARS-CoV-2, and  from 20 as control group. Multiple of liver and kidney biomarker was measured to demonstrated the adverse consequence ‎of ‎‎(SARS-CoV-2). And shedding light on the influences that occurred on the values of biomarkers of both liver and kidney function.

The clinical measuring of liver function involved Alanine aminotransferase (ALT) ‎‎(80.308±69.334) aspartate aminotransferase ‎‎(AST) (60.205±48.013), Lactate Dehydrogenase (LDH) (773.667±437.657), C-reactive protein (CRP) (64.205±37.327), which were significantly ‎high with (p<0.01) and ‎Alkaline phosphate (ALP) (404.590±339.462)  was significantly high with (p < 0.009) and albumin level (2.982±0.629) had decreased with (p<‎‎0.003) as comparing with control group. The kidney ‎dysfunction was evaluated by Serum levels of urea (76.056±59.827) and creatinine (1.570±0.947), both were highly ‎significant with (p<‎‎0.004), (p<0.001) respectively when compared with control group.  percentage level of elevating or reducing in most measured biomarkers in this study was higher ‎than from the previous studies. ‎ In ‎this manuscript, we analyzed the adverse consequences of covid-19 developed from the virus ‎itself or the ‎strategy protocol of drugs utilized that might induce liver and kidney damage in COVID-19 ‎Iraqi individuals. in ‎other words‎, We presented the clinical management aimed at demonstrating the organ ‎damage caused by ‎COVID-19 and anti-COVID-19 pharmacological therapies utilized.‎

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Published

2022-11-28 — Updated on 2022-12-13

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How to Cite

Omar Falah Ibrahim. (2022). The Adverse consequence of covid-19 causing liver and kidney dysfunctions. Tikrit Journal of Pure Science, 27(5), 1–6. https://doi.org/10.25130/tjps.v27i5.12 (Original work published November 28, 2022)