The Adverse consequence of covid-19 causing liver and kidney dysfunctions
DOI:
https://doi.org/10.25130/tjps.v27i5.12Keywords:
(consequence of covid-19; multi-organ injury; covid-19 and kidney failure; covid-19 and liver injury; drugs adverse)Abstract
The COVID-19 outbreak is a substantial public health concern around the world. The most common complication of COVID-19 infection is lung damage. However, damage can occur in other organs, including liver, cardiac dysfunction, kidney dysfunction, and intestine disorder. This research aims is to evaluate the function of two main organs in the human body, the liver, and kidney, assess the organ's function by measuring the clinical features and test abnormalities in COVID-19 patients, and to compared with previous publications, and highlighted on adverse of pharmacological utilized in the treatment of covid-19 patients. This study included collcting the blood from 60 patients with an average age of (58.718) was admitted between August and December 2021 to Al-Shefa hospital in Al-Ramadi city with a severe infection of SARS-CoV-2, and from 20 as control group. Multiple of liver and kidney biomarker was measured to demonstrated the adverse consequence of (SARS-CoV-2). And shedding light on the influences that occurred on the values of biomarkers of both liver and kidney function.
The clinical measuring of liver function involved Alanine aminotransferase (ALT) (80.308±69.334) aspartate aminotransferase (AST) (60.205±48.013), Lactate Dehydrogenase (LDH) (773.667±437.657), C-reactive protein (CRP) (64.205±37.327), which were significantly high with (p<0.01) and Alkaline phosphate (ALP) (404.590±339.462) was significantly high with (p < 0.009) and albumin level (2.982±0.629) had decreased with (p<0.003) as comparing with control group. The kidney dysfunction was evaluated by Serum levels of urea (76.056±59.827) and creatinine (1.570±0.947), both were highly significant with (p<0.004), (p<0.001) respectively when compared with control group. percentage level of elevating or reducing in most measured biomarkers in this study was higher than from the previous studies. In this manuscript, we analyzed the adverse consequences of covid-19 developed from the virus itself or the strategy protocol of drugs utilized that might induce liver and kidney damage in COVID-19 Iraqi individuals. in other words, We presented the clinical management aimed at demonstrating the organ damage caused by COVID-19 and anti-COVID-19 pharmacological therapies utilized.
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- 2022-12-13 (2)
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