Protective role of CoQ10 in reducing the side effects resulting from the use of Tramadol on some immunological variables in the endemic female rabbits

Authors

  • Hanan Shihab Ahmad Hussain
  • Zaid M.Mubark AL-Mahdawi
  • Muneef Saab Ahmed Aljanabi

DOI:

https://doi.org/10.25130/tjps.v22i7.826

Abstract

The aim of study to determine out the role of CoQ10 in reducing the side effects from the use of Tramadol on the level of Interlukin IL-6, IL-10 and PGF2α the study included 30 endemic female rabbits, where each group included  5 animals. The results showed increase with a highly significant with (P≤0.01) in the concentration of IL-10 in sera of treated group with tramadol (initial dose) and group treated tramadol (double dose) group treated tramadol (initial dose + CoQ10) and group treated  with tramadol (double dose + CoQ10) compare with control.

The results showed no significant differences in the concentration of IL-10 in sera of treated group with Co Q10 compare with control. The results revealed  high significant increase  (P≤0.01) in the concentration of IL-6 in the sera of the treated group with  tramadol (double dose) group treated with  tramadol (initial dose + COQ10) as compared with the control and the results showed the presence of high significant decrease (P≤0.01) in the concentration of IL-6 in the sera of the group treated with tramadol (initial dose) and treated with group tramadol (double dose + COQ10) compare with control. the results showed there were no significant differences in the concentration of IL-6 in serum of group treated with CoQ10 as compare with control. Results indicated occurrence of high significant increase (P≤0.01) in a concentration of PGF 2α in serum of the group  treated with tramadol (initial dose) and group treated with tramadol (double dose)and group treated with tramadol (initial dose + CoQ10) and group treated with tramadol (double dose +CoQ10) compare with control. The results showed presence of a highly significant decrease (P≤0.01) in the concentration of P G F 2α in sera of group treated  with  CoQ10 as compare with control.

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Published

2023-02-01

How to Cite

Hanan Shihab Ahmad Hussain, Zaid M.Mubark AL-Mahdawi, & Muneef Saab Ahmed Aljanabi. (2023). Protective role of CoQ10 in reducing the side effects resulting from the use of Tramadol on some immunological variables in the endemic female rabbits. Tikrit Journal of Pure Science, 22(7), 7–12. https://doi.org/10.25130/tjps.v22i7.826

Issue

Vol. 22 No. 7 (2017)

Section

Articles

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Copyright (c) 2023 Tikrit Journal of Pure Science

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