Preparation, Identification and study Antibacterial Activity of Some new 2,3- Dihydroquinazolin-4 (1H)-one Derivatives
DOI:
https://doi.org/10.25130/tjps.v23i9.812Abstract
In this study some new compounds have been prepared including the
reaction of diazoium salt of 1,4-phenylenediamine with 2-
mercaptobenzaldehyde at (0-5)0C[F1]. Then Schiff bases [F2-F6] were
then synthesized through the reaction of compound [F1] with
substituteds aniline in absolute ethanol, and Schiff bases were converted
into 2,3 - dihyroquinazolin - 4(1H) - one derivatives [F7-F11] by the
reaction with 2-amino benzoic acid in ethanol. The prepared compounds
were characterized by color and melting point, FT-IR, UV-Vis spectral
analysis. Some of the prepared compounds were identified by 1H-NMR
spectra and C.H.N analysis. The antibacterial activities were studied
against different kinds of bacteria, in addition, the stability of prepared
dyes which proved to be of high stability and bright colors was studies,
in addition the conformation of prepared compounds at the lower energy
level were studied.
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