Spectrophotometric Determination of Cefixime by Oxidative Coupling Reaction with 4-Aminophenol in the Presence of Potassium periodate

Authors

  • Ali Ibraheem Khaleel
  • Heba Ibrahim Abdulla

DOI:

https://doi.org/10.25130/tjps.v22i3.720

Abstract

This work involves  a new simple, rapid and sensitive spectrophotometric method for the determination of Cefixem. The method based on the oxidative coupling reaction between Cefixime and 4-Aminophenol using Potassium periodate as oxidizing agent to form a violet color water soluble product that has a maximum absorption at 537 nm. The optimum conditions were:, pH 6.5, temperature between 25-30 oC. Beer’s law is obeyed in a concentration range of 4 to 30 µg / ml with a molar absorptivity of 6749.75 L.mol-1. cm-1. The relative error was  0.729 to - 0.752 % and a relative standard deviation of 0.556 to  0.861% ,DL= 0.136 µg / ml. The proposed method has been successfully applied to the determination of Cefixime in SAMAXIME Capsules with recovery of not less than 98.1%.

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Published

2023-01-27

How to Cite

Ali Ibraheem Khaleel, & Heba Ibrahim Abdulla. (2023). Spectrophotometric Determination of Cefixime by Oxidative Coupling Reaction with 4-Aminophenol in the Presence of Potassium periodate. Tikrit Journal of Pure Science, 22(3), 111–118. https://doi.org/10.25130/tjps.v22i3.720

Issue

Vol. 22 No. 3 (2017)

Section

Articles

License

Copyright (c) 2023 Tikrit Journal of Pure Science

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