Determination of Salbutamol Using Spectrophotometric Method Depending on Chromium-1,5-diphenylcarbazide Complex
DOI:
https://doi.org/10.25130/tjps.v25i5.290Keywords:
Salbutamol, spectrophotometric, 1,5-diphenylcarbazide.Abstract
A rapid, simple, accurate, and economized spectrophotometric method for the determination of salbutamol sulfate(SAL) has been suggest using an oxidation-reduction reaction. This method depends on the oxidation of SAL medication with an excess amount of chromate (CrO42- ) as an oxidant agent in the acidic medium of 2N Sulphuric acid and the presence of Sodium oxalate as a catalyst of the oxidation process. Then the remaining quantity of chromate will be reacted with 1,5-diphenylcarbazide to form a pink-reddish and stable water-soluble complex which is exhibiting maximum absorption at 543 nanometers. The optimum conditions for the present work were studied experimentally. The linearity of the proposed method follows Beer’s law in the concentration range of 50 to 900 μg in a final volume of 25ml with a molar absorptivity which is equal to 0.538×104 l.mol-1.cm-1. The proposed method shows good recovery values, accuracy, and precision. The present method was so good to be successfully applied for the determination of SAL medication in its pure form and pharmaceutical preparations.
Downloads
Published
How to Cite
License
Copyright (c) 2022 Tikrit Journal of Pure Science
This work is licensed under a Creative Commons Attribution 4.0 International License.
Tikrit Journal of Pure Science is licensed under the Creative Commons Attribution 4.0 International License, which allows users to copy, create extracts, abstracts, and new works from the article, alter and revise the article, and make commercial use of the article (including reuse and/or resale of the article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made, and the licensor is not represented as endorsing the use made of the work. The authors hold the copyright for their published work on the Tikrit J. Pure Sci. website, while Tikrit J. Pure Sci. is responsible for appreciate citation of their work, which is released under CC-BY-4.0, enabling the unrestricted use, distribution, and reproduction of an article in any medium, provided that the original work is properly cited.
