Determination of Meropenem by Spectrophotometric-Application to Pharmaceutical Preparations

Authors

  • Nada A. Khalil
  • Walada H. Ibrahim

DOI:

https://doi.org/10.25130/tjps.v25i1.215

Keywords:

Meropenem, spectrophotometry, charge transfer

Abstract

A simple and sensitive spectrophotometric method was described for the determination of Meropenem in pure and in pharmaceutical formulations. 2,3 dichloro 5,6 dicyano 1,4 benzoquinone(DDQ)has been used for determination of meropenem by formation of charge transfer complex measured at 345 nm.Beer᾽s law is obeyed in the concentration range of (0.625-12.5µg/ml) The molar absorptivity (2.3889×104)l.mol1-.cm1-,Sandellʹs sensitivity index is 0.0161µg.cm2-,The method is precise (relative standard deviation RSD% is better than ±3.32%) and accurate (relative error in the range of -0.97 to-0.60%)  depending on the concentration  level.

The method was applied succefully to the assay of Meropenem in pharmaceutical preparation in the form of injection.

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Published

2020-02-02

How to Cite

Nada A. Khalil, & Walada H. Ibrahim. (2020). Determination of Meropenem by Spectrophotometric-Application to Pharmaceutical Preparations. Tikrit Journal of Pure Science, 25(1), 68–74. https://doi.org/10.25130/tjps.v25i1.215

Issue

Vol. 25 No. 1 (2020)

Section

Articles

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