Spectrophotometric Determination for Salbutamol Sulphate drug by Oxidation Coupling with 4-Aminoantipyrine

Authors

  • Asmaa Ahmed Mohammed

DOI:

https://doi.org/10.25130/tjps.v21i5.1034

Abstract

This research introduce simple & fast spectrophotometric method for determination of Salbutamol Sulphate drug by Oxidation Coupling with 4-aminoantipyrine(4-AAP) and NaIO4 as Oxidant reagent. Purple color solution is found which give maximum absorbance  at 506 nm.

The optimum conditions of the method are as the follow :

(2 µg/ml, 2.4X10-3 M and 4.8X10-3 M) concentration of drug ,reagent and oxidation reagent respectively with 4min as a reaction time at room temperature in neutrality solution.

The results of statistical treatment of linear concentration range  (0.4- 40) µg/ml are: r= 0.9984, Detection limit = 0.0317 µg/ml and Molar absorption coefficient =19028 L/mol.cm , This method is applied successfully for the  determination drug in pharmaceutical formulation with ratio 1:1.

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Published

2023-02-06

How to Cite

Asmaa Ahmed Mohammed. (2023). Spectrophotometric Determination for Salbutamol Sulphate drug by Oxidation Coupling with 4-Aminoantipyrine. Tikrit Journal of Pure Science, 21(5), 93–96. https://doi.org/10.25130/tjps.v21i5.1034

Issue

Vol. 21 No. 5 (2016)

Section

Articles

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Copyright (c) 2023 Tikrit Journal of Pure Science

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