Synthesis and Characterization of some New Amic acid and Imides and study the Biological Activity

Abstract

This study includs the synthesis of some new Amic acid and Imides,
starting from the esters [S1] of Terephthalic acid which then converted to
its hydrazide [S2] then to amic acid derivatives [S3-S7] and finally with
imides [S8-S12]. Preparing of ester [S1] by usual esterification of
terephthalic acid with absolute ethanol in acidic medium, then has
converted to its hydrazide [S2] by reacting it with hydrazine hydrate. The
amic acid derivatives [S3-S7] have been synthesized by the reaction of
hydrazide [S2] with anhydrides (2,3-dimethyl malic anhydride, 3-nitro
phthalic anhydride, hexahydro phthalic anhydride, Diphenic anhydride,
tetra Phenyl phthalic anhydride) in diethyl ether. Imides [S8-S12] were
also synthesized by cyclization of amic acids derivatives using acetic
acid anhydride and anhydrous sodium acetate. The synthesized
compounds were identified by spectral methods UV, FT-IR and H1-
NMR beside melting point and the purity was determined using (TLC)
and some of its physical properties were measured. Some of these
compounds were tested against four strains of bacteria (E. coli, P.
ariginosa, S. aurous and S. pyogenes)