The Synthesis of Some Imine Derivatives via Condensation Reactions between Some Aromatic Phenylhydroxylamine Derivatives with Glyoxylic Acid and the Study of their biological activity
DOI:
https://doi.org/10.25130/tjps.v28i6.1411Keywords:
Condensation reactions, Glyoxalic acid, imine, biological activityAbstract
This study investigated the condensation reactions between N-(3,4-dimethoxybenzyl)hydroxylamine and N-(4-methylbenzyl)hydroxylamine with glyoxalic acid. The objective was to obtain imine derivatives as the desired target products. FT-IR, 1H-NMR, and 13C-NMR spectroscopic techniques were used to identify the structures of the produced compounds. Different conditions were considered for these reactions and only N-(3,4-dimethoxybenzyl)hydroxylamine could be converted to the desired nitrone. Finally, the antimicrobial efficacy was assessed in terms of its action against the bacteria Escherichia coli (E.coli) as Gram-negative bacteria, Staphylococcus aureus (S.aureus) as Gram-positive bacteria and fungus (Candida albicans). The activity data proved that this nitrone showed significant antimicrobial activity compared to standard drugs.
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