Preparation, Characterization, Anti-cancer and Antibacterial Evaluation of New Schiff base and Tetrazole Derivatives
DOI:
https://doi.org/10.25130/tjps.v28i2.1333Keywords:
Anticancer, Schiff base, Tetrazole, Anti-bacterial, AzoAbstract
This work involved the synthesis of tetrazole derivatives 4,4'-(((sulfonylbis(4,1-phenylene))bis(diazene-2,1-dil))bis(2-(1-(4-R)phenyl]-4),5-Dihydro-1H-tetrazol-5-yl(phenol) (where R = OH or OCH3) through the reaction of the substituted amine in THF as a solvent with sodium azide. FT-IR 1H-NMR Spectrophotometric methods were used to characterize the prepared compounds. The antibacterial activity against four types of bacteria was studied. It was proven that tetrazole compounds were more effective than the compounds from which they were derived. The anticancer activity was measured against MCF-7 strains of human breast cells of the synthesized compounds.
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