Synthesis of new thioester derivative of aspirin and study its effect on some biochemical parameters in blood serum of rabbits
Abstract
This presented work was included synthesis of new thioester derivatives by reaction of Aspirin (a non-steroidal anti-inflammatory drugs) (NSAIDs) and Captopril as a carrier which is used as an antihypertensive drug and an inhibitor for angiotensin-converting enzyme (ACE). Aspirin was converted into acid chloride of aspirin then reacted with SH group of captopril to afforded of 1-(3-((2-acetoxybenzoyl)thio)-2-methylpropanoyl)pyrrolidine-2-carboxylic acid and characterized by FT-IR and 1HNMR spectroscopy. The effect of synthesized compound was studied on some biochemical parameters in the blood serum of rabbits. Results of this study indicated: significant increase in the level of total fucose, total protein and globulin. Non- significant increase in the level of albumin, creatinine, glutathione and uric acid, significant decrease in level of Triglycerides and non-significant decrease in the level of Cholesterol, and malondialdehyde.
