Synthesis of new thioester derivative of aspirin and study its effect on some biochemical parameters in blood serum of rabbits

  • Zaid Abdalkader Dawood1
  • , Firas Shawqi Algburi2
  • Nazar Ahmad Naji1

Abstract

This presented work was included synthesis of new thioester derivatives by reaction of Aspirin (a non-steroidal anti-inflammatory drugs) (NSAIDs) and Captopril as a carrier which is used as an antihypertensive drug and an inhibitor for angiotensin-converting enzyme (ACE). Aspirin was converted into acid chloride of aspirin then reacted with SH group of captopril to afforded of 1-(3-((2-acetoxybenzoyl)thio)-2-methylpropanoyl)pyrrolidine-2-carboxylic acid and characterized by FT-IR and 1HNMR spectroscopy. The effect of synthesized compound was studied on some biochemical parameters in the blood serum of rabbits. Results of this study indicated: significant increase in the level of total fucose, total protein and globulin.   Non- significant increase in the level of albumin, creatinine, glutathione and uric acid, significant decrease in level of Triglycerides and non-significant decrease in the level of Cholesterol, and malondialdehyde. 


 


http://dx.doi.org/10.25130/tjps.27.2022.019   

Published
Jun 2, 2022
How to Cite
DAWOOD1, Zaid Abdalkader; ALGBURI2, , Firas Shawqi; NAJI1, Nazar Ahmad. Synthesis of new thioester derivative of aspirin and study its effect on some biochemical parameters in blood serum of rabbits. Tikrit Journal of Pure Science, [S.l.], v. 27, n. 2, p. 16-22, june 2022. ISSN 2415-1726. Available at: <https://tjps.tu.edu.iq/index.php/j/article/view/1278>. Date accessed: 04 july 2022. doi: http://dx.doi.org/10.25130/j.v27i2.1278.
Section
Articles