Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole

  • Taghreed Hazem Saber Alfakje1
  • Ali Ashgar Abed AL_Mteewati2
  • Faehaa A. Al-Mashhadane1

Abstract

Adenosine is a nucleoside which occurs naturally in a diverse forms in all cells of the body and in most biological fluids. Under basal conditions, the extracellular adenosine concentration is maintained within certain limits. Dipyridamol inhibits adenosine reuptake by erythrocytes, endothelial cells and platelet increasing plasma levels of adenosine Aims: study the effects of adenosine and dipyridamole on serum levels of serum urea, creatinine, alkaline phosphatase(ALP), lactate dehydrogenase (LDH), Aspartate Aminotransferase (GOT), and Alanine Aminotransferase (GPT). Material and methods: Thirty-five male rabbits were included in the study. The animals were divided into 3 groups: Group one(5 animals): injected intraperitoneal  (i.p) with 2 ml of distilled water/day (control group). Group two (15 animals): were treated by i.p  injection of adenosine, they were divided into 3 sub groups (5 animals) according to adenosine dose:1 mg/kg, 2mg/kg and 4 mg/kg.Group 3 (15 animals):  were treated by dipyridamole orally, they were divided into 3 sub-groups (5 animals) according to dipyridamole dose:4 mg/kg, 8 mg/kg and 12 mg/kg. Result: Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels.  While statistical analysis of serum levels of S. creatinine and ALP showed no significant differences among 3 study groups. Conclusion: both adenosine, dipyridamole cause Significant differences among 3 groups were found in blood urea, LDH, GOT levels, and in GPT levels in rabbit


 


http://dx.doi.org/10.25130/tjps.26.2021.044  

Published
Jul 10, 2021
How to Cite
ALFAKJE1, Taghreed Hazem Saber; AL_MTEEWATI2, Ali Ashgar Abed; AL-MASHHADANE1, Faehaa A.. Effects of adenosine and dipyridamole on serum levels of some biochemical markers in rabbits: Running title: Biochemical effects of adenosine and dipyridamole. Tikrit Journal of Pure Science, [S.l.], v. 26, n. 3, p. 18-25, july 2021. ISSN 2415-1726. Available at: <https://tjps.tu.edu.iq/index.php/j/article/view/1145>. Date accessed: 22 sep. 2021. doi: http://dx.doi.org/10.25130/j.v26i3.1145.
Section
Articles