Preparation, Identification and study Antibacterial Activity of Some new 2,3- Dihydroquinazolin-4 (1H)-one Derivatives
Abstract
In this study some new compounds have been prepared including the reaction of diazoium salt of 1,4-phenylenediamine with 2-mercaptobenzaldehyde at (0-5)0C[F1]. Then Schiff bases [F2-F6] were then synthesized through the reaction of compound [F1] with substituteds aniline in absolute ethanol, and Schiff bases were converted into 2,3 - dihyroquinazolin - 4(1H) - one derivatives [F7-F11] by the reaction with 2-amino benzoic acid in ethanol. The prepared compounds were characterized by color and melting point, FT-IR, UV-Vis spectral analysis. Some of the prepared compounds were identified by 1H-NMR spectra and C.H.N analysis. The antibacterial activities were studied against different kinds of bacteria, in addition, the stability of prepared dyes which proved to be of high stability and bright colors was studies, in addition the conformation of prepared compounds at the lower energy level were studied.
