Effect of the addition of silver nanoparticles on the biological activity of thiocarbohydrazide derivatives

Abstract

Thiocarbohydrazide (TCH) derivatives [(II), (III) and (IV)] were prepared and characterized by X-RAY diffraction (XRD), infra-red spectrum (FTIR). Also silver nanoparticles was prepared by chemical reduction and characterized by X-RAY diffraction (XRD), infra-red spectrum (FTIR), atomic force microscope (AFM) and scanning electron microscope (SEM). Thiocarbohydrazide derivatives were functionalized with silver nanoparticles by sonication. The pure and functionalized TCH derivatives were used to study the biological activity against Staphylococcus aureus bacteria. The functionalized compounds with Ag nanoparticles have more Inhibition effect against Staphylococcus aureus than unfunctionalized compounds due to the small size and high surface area of Ag nanoparticles.