Determination of MDA as oxidative stress marker and most common type of blood group in asthmatic patients before and after treatment with montelukast drug.

Abstract

Asthma is a complex chronic inflammatory disorder of airways characterized by airway smooth muscle hypertrophy, hyperplasia and over production of mucous in which many cells and cellular elements play an important role.

The aim of the study is to monitor the changes in asthmatic patients before and after treatment with montelukast in the MDA level as oxidative stress marker in asthmatic cases, and the most common type of blood group. The total number of subjects included in this study was two hundred with acute asthma. The major part of this study represents a follow up study.

Subjects with bronchial asthma were previously diagnosed but not on regular treatment, their aged ranged between (16 – 50) years attending the respiratory unit directly at tikrit teaching hospital. The period of data collection was from first of April of 2013 up to the mid of June- 2014.

 There is a significant change in level of MDA, during the asthmatic attacks (1.12± 0.42, while after treatment (0.6 ± 0.34 P ≤ 0.001). The most common type of blood group in asthmatic cases is type O which about 69% from total number of cases , type A about 18.5%, type B about 9% , and type AB about 3.5%).